Identification of the Amino Acids 300–600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

Phosphorylation of insulin receptor substrate (IRS)-2 on tyrosine residues is a key event in IGF-1/insulin signaling and leads to activation of the PI 3-kinase and the Ras/MAPK pathway. Furthermore, phosphorylated serine/threonine residues on IRS-2 can induce 14-3-3 binding. In this study we searche...

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Main Authors: Neukamm, Sabine S., Toth, Rachel, Morrice, Nick, Campbell, David G., MacKintosh, Carol, Lehmann, Rainer, Haering, Hans-Ulrich, Schleicher, Erwin D., Weigert, Cora
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422239/
https://ncbi.nlm.nih.gov/pubmed/22912850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043296
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