Decorin Antagonizes IGF Receptor I (IGF-IR) Function by Interfering with IGF-IR Activity and Attenuating Downstream Signaling

We have recently discovered that the insulin-like growth factor receptor I (IGF-IR) is up-regulated in human invasive bladder cancer and promotes migration and invasion of transformed urothelial cells. The proteoglycan decorin, a key component of the tumor stroma, can positively regulate the IGF-IR...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Iozzo, Renato V., Buraschi, Simone, Genua, Marco, Xu, Shi-Qiong, Solomides, Charalambos C., Peiper, Stephen C., Gomella, Leonard G., Owens, Rick C., Morrione, Andrea
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186372/
https://ncbi.nlm.nih.gov/pubmed/21840990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262766
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker