Decorin Antagonizes the Angiogenic Network: CONCURRENT INHIBITION OF MET, HYPOXIA INDUCIBLE FACTOR 1α, VASCULAR ENDOTHELIAL GROWTH FACTOR A, AND INDUCTION OF THROMBOSPONDIN-1 AND TIMP3

Decorin, a small leucine-rich proteoglycan, inhibits tumor growth by antagonizing multiple receptor tyrosine kinases including EGFR and Met. Here, we investigated decorin during normoxic angiogenic signaling. An angiogenic PCR array revealed a profound decorin-evoked transcriptional inhibition of pr...

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Bibliographische Detailangaben
Hauptverfasser: Neill, Thomas, Painter, Hannah, Buraschi, Simone, Owens, Rick T., Lisanti, Michael P., Schaefer, Liliana, Iozzo, Renato V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285326/
https://ncbi.nlm.nih.gov/pubmed/22194599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283499
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