Decorin Antagonizes the Angiogenic Network: CONCURRENT INHIBITION OF MET, HYPOXIA INDUCIBLE FACTOR 1α, VASCULAR ENDOTHELIAL GROWTH FACTOR A, AND INDUCTION OF THROMBOSPONDIN-1 AND TIMP3

Decorin, a small leucine-rich proteoglycan, inhibits tumor growth by antagonizing multiple receptor tyrosine kinases including EGFR and Met. Here, we investigated decorin during normoxic angiogenic signaling. An angiogenic PCR array revealed a profound decorin-evoked transcriptional inhibition of pr...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Neill, Thomas, Painter, Hannah, Buraschi, Simone, Owens, Rick T., Lisanti, Michael P., Schaefer, Liliana, Iozzo, Renato V.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
Glycobiology and Extracellular Matrices
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285326/
https://ncbi.nlm.nih.gov/pubmed/22194599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.283499
תגים: הוספת תג
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

פריטים דומים