Decorin Induces Mitophagy in Breast Carcinoma Cells via Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and Mitostatin

Tumor cell mitochondria are key biosynthetic hubs that provide macromolecules for cancer progression and angiogenesis. Soluble decorin protein core, hereafter referred to as decorin, potently attenuated mitochondrial respiratory complexes and mitochondrial DNA (mtDNA) in MDA-MB-231 breast carcinoma...

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Hlavní autoři: Neill, Thomas, Torres, Annabel, Buraschi, Simone, Owens, Rick T., Hoek, Jan B., Baffa, Raffaele, Iozzo, Renato V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931056/
https://ncbi.nlm.nih.gov/pubmed/24403067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.512566
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