Decorin Antagonizes IGF Receptor I (IGF-IR) Function by Interfering with IGF-IR Activity and Attenuating Downstream Signaling

We have recently discovered that the insulin-like growth factor receptor I (IGF-IR) is up-regulated in human invasive bladder cancer and promotes migration and invasion of transformed urothelial cells. The proteoglycan decorin, a key component of the tumor stroma, can positively regulate the IGF-IR...

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Détails bibliographiques
Auteurs principaux: Iozzo, Renato V., Buraschi, Simone, Genua, Marco, Xu, Shi-Qiong, Solomides, Charalambos C., Peiper, Stephen C., Gomella, Leonard G., Owens, Rick C., Morrione, Andrea
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186372/
https://ncbi.nlm.nih.gov/pubmed/21840990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.262766
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