Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR

AS160 (Akt substrate of 160 kDa) mediates insulin-stimulated GLUT4 (glucose transporter 4) translocation, but is widely expressed in insulin-insensitive tissues lacking GLUT4. Having isolated AS160 by 14-3-3-affinity chromatography, we found that binding of AS160 to 14-3-3 isoforms in HEK (human emb...

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Autori principali: Geraghty, Kathryn M., Chen, Shuai, Harthill, Jean E., Ibrahim, Adel F., Toth, Rachel, Morrice, Nick A., Vandermoere, Franck, Moorhead, Greg B., Hardie, D. Grahame, MacKintosh, Carol
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2049023/
https://ncbi.nlm.nih.gov/pubmed/17617058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070649
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