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Loss of Endothelial Furin Leads to Cardiac Malformation and Early Postnatal Death
In mammals, seven proprotein convertases (PCs) cleave secretory proteins after basic residues, and four of them are called furin-like PCs: furin, PC5, PACE4, and PC7. In vitro, they share many substrates. However, furin is essential during development since deficient embryos die at embryonic day 11...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Microbiology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422005/ https://ncbi.nlm.nih.gov/pubmed/22733989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06331-11 |
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