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Mechanism of Action of and Mechanism of Reduced Susceptibility to the Novel Anti-Clostridium difficile Compound LFF571

LFF571 is a novel semisynthetic thiopeptide and potent inhibitor of Gram-positive bacteria. We report that the antibacterial activity of LFF571 against Clostridium difficile is due to inhibition of translation. Single-step mutants of C. difficile with reduced susceptibility to LFF571 were selected a...

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Bibliografske podrobnosti
Main Authors: Leeds, J. A., Sachdeva, M., Mullin, S., Dzink-Fox, J., LaMarche, M. J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421628/
https://ncbi.nlm.nih.gov/pubmed/22644023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06354-11
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