Identification of (+)-Erythro-Mefloquine as an Active Enantiomer with Greater Efficacy than Mefloquine against Mycobacterium avium Infection in Mice

Infection caused by Mycobacterium avium is common in AIDS patients who do not receive treatment with highly active antiretroviral therapy (HAART) or who develop resistance to anti-HIV therapy. Mefloquine, a racemic mixture used for malaria prophylaxis and treatment, is bactericidal against M. avium...

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Bibliographische Detailangaben
Hauptverfasser: Bermudez, Luiz E., Inderlied, Clark B., Kolonoski, Peter, Chee, Christopher B., Aralar, Priscilla, Petrofsky, Mary, Parman, Toufan, Green, Carol E., Lewin, Anita H., Ellis, William Y., Young, Lowell S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421598/
https://ncbi.nlm.nih.gov/pubmed/22615290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00320-12
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