Thiosemicarbazole (Thiacetazone-Like) Compound with Activity against Mycobacterium avium in Mice

In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 μg/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and sp...

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Bibliographic Details
Main Authors: Bermudez, Luiz E., Reynolds, Robert, Kolonoski, Peter, Aralar, Pricilla, Inderlied, Clark B., Young, Lowell S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC166073/
https://ncbi.nlm.nih.gov/pubmed/12878542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.47.8.2685-2687.2003
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