Identification of (+)-Erythro-Mefloquine as an Active Enantiomer with Greater Efficacy than Mefloquine against Mycobacterium avium Infection in Mice

Infection caused by Mycobacterium avium is common in AIDS patients who do not receive treatment with highly active antiretroviral therapy (HAART) or who develop resistance to anti-HIV therapy. Mefloquine, a racemic mixture used for malaria prophylaxis and treatment, is bactericidal against M. avium...

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Detalhes bibliográficos
Main Authors: Bermudez, Luiz E., Inderlied, Clark B., Kolonoski, Peter, Chee, Christopher B., Aralar, Priscilla, Petrofsky, Mary, Parman, Toufan, Green, Carol E., Lewin, Anita H., Ellis, William Y., Young, Lowell S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421598/
https://ncbi.nlm.nih.gov/pubmed/22615290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00320-12
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