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CAG expansion induces nucleolar stress in polyglutamine diseases

The cell nucleus is a major site for polyglutamine (polyQ) toxicity, but the underlying mechanisms involved have yet been fully elucidated. Here, we report that mutant RNAs that carry an expanded CAG repeat (expanded CAG RNAs) induce apoptosis by activating the nucleolar stress pathway in both polyQ...

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Bibliografiske detaljer
Main Authors: Tsoi, Ho, Lau, Terrence Chi-Kong, Tsang, Suk-Ying, Lau, Kwok-Fai, Chan, Ho Yin Edwin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421186/
https://ncbi.nlm.nih.gov/pubmed/22847428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204089109
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