Učitavanje...
CAG expansion induces nucleolar stress in polyglutamine diseases
The cell nucleus is a major site for polyglutamine (polyQ) toxicity, but the underlying mechanisms involved have yet been fully elucidated. Here, we report that mutant RNAs that carry an expanded CAG repeat (expanded CAG RNAs) induce apoptosis by activating the nucleolar stress pathway in both polyQ...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3421186/ https://ncbi.nlm.nih.gov/pubmed/22847428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204089109 |
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