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CAG expansion induces nucleolar stress in polyglutamine diseases
The cell nucleus is a major site for polyglutamine (polyQ) toxicity, but the underlying mechanisms involved have yet been fully elucidated. Here, we report that mutant RNAs that carry an expanded CAG repeat (expanded CAG RNAs) induce apoptosis by activating the nucleolar stress pathway in both polyQ...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3421186/ https://ncbi.nlm.nih.gov/pubmed/22847428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204089109 |
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