Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation

Cofactors for estrogen receptor α (ERα) can modulate gene activity by posttranslationally modifying histone tails at target promoters. Here, we found that stimulation of ERα-positive cells with 17β-estradiol (E2) promotes global citrullination of histone H3 arginine 26 (H3R26) on chromatin. Addition...

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Detalhes bibliográficos
Main Authors: Zhang, Xuesen, Bolt, Michael, Guertin, Michael J., Chen, Wei, Zhang, Sheng, Cherrington, Brian D., Slade, Daniel J., Dreyton, Christina J., Subramanian, Venkataraman, Bicker, Kevin L., Thompson, Paul R., Mancini, Michael A., Lis, John T., Coonrod, Scott A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421185/
https://ncbi.nlm.nih.gov/pubmed/22853951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203280109
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