Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation

Cofactors for estrogen receptor α (ERα) can modulate gene activity by posttranslationally modifying histone tails at target promoters. Here, we found that stimulation of ERα-positive cells with 17β-estradiol (E2) promotes global citrullination of histone H3 arginine 26 (H3R26) on chromatin. Addition...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhang, Xuesen, Bolt, Michael, Guertin, Michael J., Chen, Wei, Zhang, Sheng, Cherrington, Brian D., Slade, Daniel J., Dreyton, Christina J., Subramanian, Venkataraman, Bicker, Kevin L., Thompson, Paul R., Mancini, Michael A., Lis, John T., Coonrod, Scott A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2012
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421185/
https://ncbi.nlm.nih.gov/pubmed/22853951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203280109
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