Synthesis and Biological Activity of N(6)-(p-Sulfophenyl)alkyl and N(6)-Sulfoalkyl Derivatives of Adenosine: Water-Soluble and Peripherally Selective Adenosine Agonists

A series of N(6)-(p-sulfophenyl)alkyl and N(6)sulfoalkyl derivatives of adenosine was synthesized, revealing that N(6)-(p-sulfophenyl)adenosine (10b) is a moderately potent (K(i) vs [(3)H]PIA in rat cortical membranes was 74 nM) and A(1)-selective (120-fold) adenosine agonist, of exceptional aqueous...

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Detalhes bibliográficos
Main Authors: Jacobson, Kenneth A., Nikodijevic, Olga, Ji, Xiao-duo, Berkich, Deborah A., Eveleth, David, Dean, Reginald L., Hiramatsu, Ken-Ichiro, Kassell, Neal F., van Galen, Philip J. M., Lee, Kevin S., Bartus, Raymond T., Daly, John W., LaNoue, Kathryn F., Maillard, Michel
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420980/
https://ncbi.nlm.nih.gov/pubmed/1433217
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