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Heat shock protein 90α (HSP90α), a substrate and chaperone of DNA-PK necessary for the apoptotic response

The “apoptotic ring” is characterized by the phosphorylation of histone H2AX at serine 139 (γ-H2AX) by DNA-dependent protein kinase (DNA-PK). The γ-H2AX apoptotic ring differs from the nuclear foci patterns observed in response to DNA-damaging agents. It contains phosphorylated DNA damage response p...

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Bibliografski detalji
Glavni autori: Solier, Stéphanie, Kohn, Kurt W., Scroggins, Bradley, Xu, Wanping, Trepel, Jane, Neckers, Leonard, Pommier, Yves
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420188/
https://ncbi.nlm.nih.gov/pubmed/22753480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1203617109
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