Igf2 ligand dependency of Pten(+/−) developmental and tumour phenotypes in the mouse

The tumour suppressor PTEN is a key negative regulator of the PI3K-Akt pathway, and is frequently either reduced or lost in human tumours. Murine genetic studies have confirmed that reduction of Pten promotes tumourigenesis in multiple organs, and demonstrated dependency of tumour development on the...

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Detalhes bibliográficos
Main Authors: Church, D N, Phillips, B R, Stuckey, D J, Barnes, D J, Buffa, F M, Manek, S, Clarke, K, Harris, A L, Carter, E J, Hassan, A B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419984/
https://ncbi.nlm.nih.gov/pubmed/22120709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.526
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