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Igf2 ligand dependency of Pten(+/−) developmental and tumour phenotypes in the mouse
The tumour suppressor PTEN is a key negative regulator of the PI3K-Akt pathway, and is frequently either reduced or lost in human tumours. Murine genetic studies have confirmed that reduction of Pten promotes tumourigenesis in multiple organs, and demonstrated dependency of tumour development on the...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3419984/ https://ncbi.nlm.nih.gov/pubmed/22120709 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.526 |
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