Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation

AIMS: Phosphatase and tensin homolog (PTEN) is implicated as a negative regulator of vascular smooth muscle cell (SMC) proliferation and injury-induced vascular remodelling. We tested if selective depletion of PTEN only in SMC is sufficient to promote SMC phenotypic modulation, cytokine production,...

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Detalhes bibliográficos
Main Authors: Furgeson, Seth B., Simpson, Peter A., Park, Insun, VanPutten, Vicki, Horita, Henrick, Kontos, Christopher D., Nemenoff, Raphael A., Weiser-Evans, Mary C.M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856191/
https://ncbi.nlm.nih.gov/pubmed/20051384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvp425
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