Selective Inactivation of PTEN in Smooth Muscle Cells Synergizes With Hypoxia to Induce Severe Pulmonary Hypertension

BACKGROUND: Pulmonary vascular remodeling in pulmonary hypertension (PH) is characterized by increased vascular smooth muscle cell (SMC) and adventitial fibroblast proliferation, small vessel occlusion, and inflammatory cell accumulation. The underlying molecular mechanisms driving progression remai...

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Bibliographische Detailangaben
Hauptverfasser: Horita, Henrick, Furgeson, Seth B., Ostriker, Allison, Olszewski, Kyle A., Sullivan, Timothy, Villegas, Leah R., Levine, Michelle, Parr, Jane E., Cool, Carlyne D., Nemenoff, Raphael A., Weiser‐Evans, Mary C. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2013
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3698782/
https://ncbi.nlm.nih.gov/pubmed/23727701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000188
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