Igf2 ligand dependency of Pten(+/−) developmental and tumour phenotypes in the mouse

The tumour suppressor PTEN is a key negative regulator of the PI3K-Akt pathway, and is frequently either reduced or lost in human tumours. Murine genetic studies have confirmed that reduction of Pten promotes tumourigenesis in multiple organs, and demonstrated dependency of tumour development on the...

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Hlavní autoři: Church, D N, Phillips, B R, Stuckey, D J, Barnes, D J, Buffa, F M, Manek, S, Clarke, K, Harris, A L, Carter, E J, Hassan, A B
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419984/
https://ncbi.nlm.nih.gov/pubmed/22120709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.526
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