Igf2 pathway dependency of the Trp53 developmental and tumour phenotypes

Insulin-like growth factor 2 (IGF2) and the transformation related protein 53 (Trp53) are potent regulators of cell growth and metabolism in development and cancer. In vitro evidence suggests several mechanistic pathway interactions. Here, we tested whether loss of function of p53 leads to IGF2 liga...

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Detalhes bibliográficos
Main Authors: Haley, Victoria L, Barnes, David J, Sandovici, Ionel, Constancia, Miguel, Graham, Christopher F, Pezzella, Francesco, Bühnemann, Claudia, Carter, Emma J, Hassan, A Bassim
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3494071/
https://ncbi.nlm.nih.gov/pubmed/22674894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201101105
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