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Variable expressivity of the tumour suppressor protein TRP53 in cryopreserved human blastocysts

In a mouse model, in vitro fertilization or extended embryo culture leads to the increased expression of TRP53 in susceptible embryos. Ablation of the TRP53 gene improved embryo viability indicating that increased expression of TRP53 is a cause of the reduction of embryo viability resulting from in...

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Detalles Bibliográficos
Main Authors: Chandrakanthan, Vashe, Chami, Omar, Stojanov, Tomas, O'Neill, Chris
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2099431/
https://ncbi.nlm.nih.gov/pubmed/17939878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-7827-5-39
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