Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome

BACKGROUND: Colon cancer predisposition is associated with mutations in BRCA1. BRCA1 protein stability depends on binding to BARD1. In different cancers, expression of differentially spliced BARD1 isoforms is correlated with poor prognosis and decreased patient survival. We therefore suspected a rol...

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Autors principals: Zhang, Y-Q, Pilyugin, M, Kuester, D, Leoni, V P, Li, L, Casula, G, Zorcolo, L, Schneider-Stock, R, Atzori, L, Irminger-Finger, I
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
Matèries:
Molecular Diagnostics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419952/
https://ncbi.nlm.nih.gov/pubmed/22814582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.297
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