Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome

BACKGROUND: Colon cancer predisposition is associated with mutations in BRCA1. BRCA1 protein stability depends on binding to BARD1. In different cancers, expression of differentially spliced BARD1 isoforms is correlated with poor prognosis and decreased patient survival. We therefore suspected a rol...

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Autores principales: Zhang, Y-Q, Pilyugin, M, Kuester, D, Leoni, V P, Li, L, Casula, G, Zorcolo, L, Schneider-Stock, R, Atzori, L, Irminger-Finger, I
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
Materias:
Molecular Diagnostics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419952/
https://ncbi.nlm.nih.gov/pubmed/22814582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.297
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