Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome

BACKGROUND: Colon cancer predisposition is associated with mutations in BRCA1. BRCA1 protein stability depends on binding to BARD1. In different cancers, expression of differentially spliced BARD1 isoforms is correlated with poor prognosis and decreased patient survival. We therefore suspected a rol...

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Bibliografiske detaljer
Main Authors: Zhang, Y-Q, Pilyugin, M, Kuester, D, Leoni, V P, Li, L, Casula, G, Zorcolo, L, Schneider-Stock, R, Atzori, L, Irminger-Finger, I
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Molecular Diagnostics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419952/
https://ncbi.nlm.nih.gov/pubmed/22814582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.297
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