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Escherichia coli UmuC active site mutants: effects on translesion DNA synthesis, mutagenesis and cell survival
Escherichia coli polymerase V (pol V/UmuD'(2)C) is a low-fidelity DNA polymerase that has recently been shown to avidly incorporate ribonucleotides (rNTPs) into undamaged DNA. The fidelity and sugar selectivity of pol V can be modified by missense mutations around the “steric gate” of UmuC. Her...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3419331/ https://ncbi.nlm.nih.gov/pubmed/22784977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.06.005 |
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