Mechanisms Employed by Escherichia coli to Prevent Ribonucleotide Incorporation into Genomic DNA by Pol V

Escherichia coli pol V (UmuD′(2)C), the main translesion DNA polymerase, ensures continued nascent strand extension when the cellular replicase is blocked by unrepaired DNA lesions. Pol V is characterized by low sugar selectivity, which can be further reduced by a Y11A “steric-gate” substitution in...

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Bibliographic Details
Main Authors: McDonald, John P., Vaisman, Alexandra, Kuban, Wojciech, Goodman, Myron F., Woodgate, Roger
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493448/
https://ncbi.nlm.nih.gov/pubmed/23144626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003030
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