Escherichia coli UmuC active site mutants: effects on translesion DNA synthesis, mutagenesis and cell survival

Escherichia coli polymerase V (pol V/UmuD'(2)C) is a low-fidelity DNA polymerase that has recently been shown to avidly incorporate ribonucleotides (rNTPs) into undamaged DNA. The fidelity and sugar selectivity of pol V can be modified by missense mutations around the “steric gate” of UmuC. Her...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Kuban, Wojciech, Vaisman, Alexandra, McDonald, John P., Karata, Kiyonobu, Yang, Wei, Goodman, Myron F., Woodgate, Roger
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419331/
https://ncbi.nlm.nih.gov/pubmed/22784977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.06.005
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы