Bim Inhibits Autophagy by Recruiting Beclin 1 to Microtubules

Bim is a proapoptotic BH3-only Bcl-2 family member. In response to death stimuli, Bim dissociates from the dynein light chain 1 (DYNLL1/LC8), where it is inactive, and can then initiate Bax/Bak-mediated mitochondria-dependent apoptosis. We found that Bim depletion increases autophagosome synthesis i...

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Autors principals: Luo, Shouqing, Garcia-Arencibia, Moises, Zhao, Rui, Puri, Claudia, Toh, Pearl P.C., Sadiq, Oana, Rubinsztein, David C.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419265/
https://ncbi.nlm.nih.gov/pubmed/22742832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.05.040
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