IGF-1 receptor antagonism inhibits autophagy

Inhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target. This pathway is upstream of mTORC1, a negative regulator of autophagy. Thus, we expected au...

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Detalhes bibliográficos
Main Authors: Renna, Maurizio, Bento, Carla F., Fleming, Angeleen, Menzies, Fiona M., Siddiqi, Farah H., Ravikumar, Brinda, Puri, Claudia, Garcia-Arencibia, Moises, Sadiq, Oana, Corrochano, Silvia, Carter, Sarah, Brown, Steve D.M., Acevedo-Arozena, Abraham, Rubinsztein, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889807/
https://ncbi.nlm.nih.gov/pubmed/23804751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt300
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