Reducing Igf-1r Levels Leads To Paradoxical and Sexually Dimorphic Effects in HD Mice

Many of the neurodegenerative diseases that afflict people in later life are associated with the formation of protein aggregates. These so-called “proteinopathies” include Alzheimer’s disease (AD) and Huntington’s disease (HD). The insulin/insulin-like growth factor signalling (IIS) pathway has been...

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Main Authors: Corrochano, Silvia, Renna, Maurizio, Osborne, Georgina, Carter, Sarah, Stewart, Michelle, May, Joel, Bates, Gillian P., Brown, Steve D. M., Rubinsztein, David C., Acevedo-Arozena, Abraham
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139380/
https://ncbi.nlm.nih.gov/pubmed/25140802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105595
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