Reducing Igf-1r Levels Leads To Paradoxical and Sexually Dimorphic Effects in HD Mice

Many of the neurodegenerative diseases that afflict people in later life are associated with the formation of protein aggregates. These so-called “proteinopathies” include Alzheimer’s disease (AD) and Huntington’s disease (HD). The insulin/insulin-like growth factor signalling (IIS) pathway has been...

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Hauptverfasser: Corrochano, Silvia, Renna, Maurizio, Osborne, Georgina, Carter, Sarah, Stewart, Michelle, May, Joel, Bates, Gillian P., Brown, Steve D. M., Rubinsztein, David C., Acevedo-Arozena, Abraham
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139380/
https://ncbi.nlm.nih.gov/pubmed/25140802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105595
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