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IGF-1 receptor antagonism inhibits autophagy
Inhibition of the insulin/insulin-like growth factor signalling pathway increases lifespan and protects against neurodegeneration in model organisms, and has been considered as a potential therapeutic target. This pathway is upstream of mTORC1, a negative regulator of autophagy. Thus, we expected au...
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| Main Authors: | , , , , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Oxford University Press
2013
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3889807/ https://ncbi.nlm.nih.gov/pubmed/23804751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt300 |
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