Transfer of the UAP56 Interaction Motif of Human Cytomegalovirus pUL69 to Its Murine Cytomegalovirus Homolog Converts the Protein into a Functional mRNA Export Factor That Can Substitute for pUL69 during Viral Infection

Nucleocytoplasmic shuttling and interaction with the cellular mRNA export factor UAP56 are prerequisites for the mRNA export activity of human cytomegalovirus (HCMV) pUL69. Although the murine cytomegalovirus homolog pM69 shuttles, it fails to export mRNAs due to its inability to recruit UAP56. Howe...

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Detalhes bibliográficos
Main Authors: Zielke, Barbara, Wagenknecht, Nadine, Pfeifer, Caroline, Zielke, Katrin, Thomas, Marco, Stamminger, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416354/
https://ncbi.nlm.nih.gov/pubmed/22553320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00730-12
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