Cyclin-dependent Kinases Phosphorylate the Cytomegalovirus RNA Export Protein pUL69 and Modulate Its Nuclear Localization and Activity

Replication of human cytomegalovirus (HCMV) is subject to regulation by cellular protein kinases. Recently, we and others reported that inhibition of cyclin-dependent protein kinases (CDKs) or the viral CDK ortholog pUL97 can induce intranuclear speckled aggregation of the viral mRNA export factor,...

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Bibliografiska uppgifter
Huvudupphovsmän: Rechter, Sabine, Scott, Gillian M., Eickhoff, Jan, Zielke, Katrin, Auerochs, Sabrina, Müller, Regina, Stamminger, Thomas, Rawlinson, William D., Marschall, Manfred
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2009
Ämnen:
Protein Synthesis, Post-Translational Modification, and Degradation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659219/
https://ncbi.nlm.nih.gov/pubmed/19179338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805693200
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