Transfer of the UAP56 Interaction Motif of Human Cytomegalovirus pUL69 to Its Murine Cytomegalovirus Homolog Converts the Protein into a Functional mRNA Export Factor That Can Substitute for pUL69 during Viral Infection

Nucleocytoplasmic shuttling and interaction with the cellular mRNA export factor UAP56 are prerequisites for the mRNA export activity of human cytomegalovirus (HCMV) pUL69. Although the murine cytomegalovirus homolog pM69 shuttles, it fails to export mRNAs due to its inability to recruit UAP56. Howe...

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Hlavní autoři: Zielke, Barbara, Wagenknecht, Nadine, Pfeifer, Caroline, Zielke, Katrin, Thomas, Marco, Stamminger, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Genome Replication and Regulation of Viral Gene Expression
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416354/
https://ncbi.nlm.nih.gov/pubmed/22553320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00730-12
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