Transfer of the UAP56 Interaction Motif of Human Cytomegalovirus pUL69 to Its Murine Cytomegalovirus Homolog Converts the Protein into a Functional mRNA Export Factor That Can Substitute for pUL69 during Viral Infection

Nucleocytoplasmic shuttling and interaction with the cellular mRNA export factor UAP56 are prerequisites for the mRNA export activity of human cytomegalovirus (HCMV) pUL69. Although the murine cytomegalovirus homolog pM69 shuttles, it fails to export mRNAs due to its inability to recruit UAP56. Howe...

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Bibliographische Detailangaben
Hauptverfasser: Zielke, Barbara, Wagenknecht, Nadine, Pfeifer, Caroline, Zielke, Katrin, Thomas, Marco, Stamminger, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416354/
https://ncbi.nlm.nih.gov/pubmed/22553320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00730-12
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