Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers

BACKGROUND AND PURPOSE: DFNA2 is a frequent hereditary hearing disorder caused by loss-of-function mutations in the voltage-gated potassium channel KCNQ4 (Kv7.4). KCNQ4 mediates the predominant K(+) conductance, I(K,n), of auditory outer hair cells (OHCs), and loss of KCNQ4 function leads to degener...

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Detalhes bibliográficos
Main Authors: Leitner, Michael G, Feuer, Anja, Ebers, Olga, Schreiber, Daniela N, Halaszovich, Christian R, Oliver, Dominik
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
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Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413860/
https://ncbi.nlm.nih.gov/pubmed/21951272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01697.x
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