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Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers
BACKGROUND AND PURPOSE: DFNA2 is a frequent hereditary hearing disorder caused by loss-of-function mutations in the voltage-gated potassium channel KCNQ4 (Kv7.4). KCNQ4 mediates the predominant K(+) conductance, I(K,n), of auditory outer hair cells (OHCs), and loss of KCNQ4 function leads to degener...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Blackwell Publishing Ltd
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413860/ https://ncbi.nlm.nih.gov/pubmed/21951272 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01697.x |
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