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Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity
The slow delayed rectifier potassium current (I(Ks)) is formed by the KCNQ1 (K(v)7.1) channel, an ion channel of four α‐subunits that modulates KCNE1 β‐subunits. I(Ks) is central to the repolarization of the cardiac action potential. Loss of function mutation reducing ventricular cardiac I(Ks) cause...
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| Publicado en: | ChemMedChem |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7318133/ https://ncbi.nlm.nih.gov/pubmed/32338831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000083 |
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