Rottlerin: Structure Modifications and KCNQ1/KCNE1 Ion Channel Activity

The slow delayed rectifier potassium current (I(Ks)) is formed by the KCNQ1 (K(v)7.1) channel, an ion channel of four α‐subunits that modulates KCNE1 β‐subunits. I(Ks) is central to the repolarization of the cardiac action potential. Loss of function mutation reducing ventricular cardiac I(Ks) cause...

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Publicado en:ChemMedChem
Main Authors: Lübke, Marco, Schreiber, Julian A., Le Quoc, Thang, Körber, Florian, Müller, Jasmin, Sivanathan, Sivatharushan, Matschke, Veronika, Schubert, Janina, Strutz‐Seebohm, Nathalie, Seebohm, Guiscard, Scherkenbeck, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Full Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7318133/
https://ncbi.nlm.nih.gov/pubmed/32338831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000083
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