Ion channel regulation by phosphoinositides analyzed with VSPs—PI(4,5)P(2) affinity, phosphoinositide selectivity, and PI(4,5)P(2) pool accessibility

The activity of many proteins depends on the phosphoinositide (PI) content of the membrane. E.g., dynamic changes of the concentration of PI(4,5)P(2) are cellular signals that regulate ion channels. The susceptibility of a channel to such dynamics depends on its affinity for PI(4,5)P(2). Yet, measur...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Rjasanow, Alexandra, Leitner, Michael G., Thallmair, Veronika, Halaszovich, Christian R., Oliver, Dominik
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472987/
https://ncbi.nlm.nih.gov/pubmed/26150791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00127
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