A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases

Voltage sensitive phosphatases (VSPs), including engineered voltage sensitive PTEN, are excellent tools to rapidly and reversibly alter the phosphoinositide (PI) content of the plasma membrane in vivo and study the tumor suppressor PTEN. However, widespread adoption of these tools is hampered by the...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Mavrantoni, Angeliki, Thallmair, Veronika, Leitner, Michael G., Schreiber, Daniela N., Oliver, Dominik, Halaszovich, Christian R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379879/
https://ncbi.nlm.nih.gov/pubmed/25873899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2015.00068
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