Systemic Preconditioning by a Prolyl Hydroxylase Inhibitor Promotes Prevention of Skin Flap Necrosis via HIF-1-Induced Bone Marrow-Derived Cells

BACKGROUND: Local skin flaps often present with flap necrosis caused by critical disruption of the blood supply. Although animal studies demonstrate enhanced angiogenesis in ischemic tissue, no strategy for clinical application of this phenomenon has yet been defined. Hypoxia-inducible factor 1 (HIF...

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Библиографические подробности
Главные авторы: Takaku, Mitsuru, Tomita, Shuhei, Kurobe, Hirotsugu, Kihira, Yoshitaka, Morimoto, Atsushi, Higashida, Mayuko, Ikeda, Yasumasa, Ushiyama, Akira, Hashimoto, Ichiro, Nakanishi, Hideki, Tamaki, Toshiaki
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413653/
https://ncbi.nlm.nih.gov/pubmed/22880134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042964
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