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Systemic Preconditioning by a Prolyl Hydroxylase Inhibitor Promotes Prevention of Skin Flap Necrosis via HIF-1-Induced Bone Marrow-Derived Cells

BACKGROUND: Local skin flaps often present with flap necrosis caused by critical disruption of the blood supply. Although animal studies demonstrate enhanced angiogenesis in ischemic tissue, no strategy for clinical application of this phenomenon has yet been defined. Hypoxia-inducible factor 1 (HIF...

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Bibliografiske detaljer
Main Authors: Takaku, Mitsuru, Tomita, Shuhei, Kurobe, Hirotsugu, Kihira, Yoshitaka, Morimoto, Atsushi, Higashida, Mayuko, Ikeda, Yasumasa, Ushiyama, Akira, Hashimoto, Ichiro, Nakanishi, Hideki, Tamaki, Toshiaki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413653/
https://ncbi.nlm.nih.gov/pubmed/22880134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042964
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