Systemic Preconditioning by a Prolyl Hydroxylase Inhibitor Promotes Prevention of Skin Flap Necrosis via HIF-1-Induced Bone Marrow-Derived Cells

BACKGROUND: Local skin flaps often present with flap necrosis caused by critical disruption of the blood supply. Although animal studies demonstrate enhanced angiogenesis in ischemic tissue, no strategy for clinical application of this phenomenon has yet been defined. Hypoxia-inducible factor 1 (HIF...

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Detaylı Bibliyografya
Asıl Yazarlar: Takaku, Mitsuru, Tomita, Shuhei, Kurobe, Hirotsugu, Kihira, Yoshitaka, Morimoto, Atsushi, Higashida, Mayuko, Ikeda, Yasumasa, Ushiyama, Akira, Hashimoto, Ichiro, Nakanishi, Hideki, Tamaki, Toshiaki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413653/
https://ncbi.nlm.nih.gov/pubmed/22880134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042964
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