Evidence that the Upf1-related molecular motor scans the 3′-UTR to ensure mRNA integrity

Upf1 is a highly conserved RNA helicase essential for nonsense-mediated mRNA decay (NMD), an mRNA quality-control mechanism that degrades aberrant mRNAs harboring premature termination codons (PTCs). For the activation of NMD, UPF1 interacts first with a translation–terminating ribosome and then wit...

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Hlavní autoři: Shigeoka, Toshiaki, Kato, Sayaka, Kawaichi, Masashi, Ishida, Yasumasa
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413143/
https://ncbi.nlm.nih.gov/pubmed/22554850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks344
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