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Evidence that the Upf1-related molecular motor scans the 3′-UTR to ensure mRNA integrity
Upf1 is a highly conserved RNA helicase essential for nonsense-mediated mRNA decay (NMD), an mRNA quality-control mechanism that degrades aberrant mRNAs harboring premature termination codons (PTCs). For the activation of NMD, UPF1 interacts first with a translation–terminating ribosome and then wit...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3413143/ https://ncbi.nlm.nih.gov/pubmed/22554850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks344 |
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