Gene Therapy by Targeted Adenovirus-mediated Knockdown of Pulmonary Endothelial Tph1 Attenuates Hypoxia-induced Pulmonary Hypertension

Serotonin is produced by pulmonary arterial endothelial cells (PAEC) via tryptophan hydroxylase-1 (Tph1). Pathologically, serotonin acts on underlying pulmonary arterial cells, contributing to vascular remodeling associated with pulmonary arterial hypertension (PAH). The effects of hypoxia on PAEC-T...

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Autors principals: Morecroft, Ian, White, Katie, Caruso, Paola, Nilsen, Margaret, Loughlin, Lynn, Alba, Raul, Reynolds, Paul N, Danilov, Sergei M, Baker, Andrew H, MacLean, Margaret R
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412483/
https://ncbi.nlm.nih.gov/pubmed/22525513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.70
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