Mice lacking the Raf-1 kinase inhibitor protein exhibit exaggerated hypoxia-induced pulmonary hypertension

BACKGROUND AND PURPOSE: Increased pulmonary vascular remodelling, pulmonary arterial pressure and pulmonary vascular resistance characterize the development of pulmonary arterial hypertension (PAH). Activation of the Raf/mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK)1/2...

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Hauptverfasser: Morecroft, I, Doyle, B, Nilsen, M, Kolch, W, Mair, K, MacLean, MR
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2011
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3130942/
https://ncbi.nlm.nih.gov/pubmed/21385176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01305.x
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