Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4

Dysregulation of cyclin-dependent kinase 4 (CDK4) and CDK6 by gain of function or loss of inhibition is common in human cancer, including multiple myeloma, but success in targeting CDK with broad-spectrum inhibitors has been modest. By selective and reversible inhibition of CDK4/CDK6, we have develo...

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Detalhes bibliográficos
Main Authors: Huang, Xiangao, Di Liberto, Maurizio, Jayabalan, David, Liang, Jun, Ely, Scott, Bretz, Jamieson, Shaffer, Arthur L., Louie, Tracey, Chen, Isan, Randolph, Sophia, Hahn, William C., Staudt, Louis M., Niesvizky, Ruben, Moore, Malcolm A. S., Chen-Kiang, Selina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412331/
https://ncbi.nlm.nih.gov/pubmed/22718837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415984
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